Date: Monday, May 25, 2015 13:00 - 14:00
Categories: Seminar
UPSC Seminars 2015
Cutting Edge Seminar

José Alonso
University of Pennsylvania and The Salk Institute for Biological Studies

The many layers of plant hormone interactions: from metabolic networks to translation regulation

Host: Karin Ljung

Room: NOTE! Stora hörsalen KB3B1

Fine-tuning of the growth and development programs with the changes in the environment is a process of critical importance for plants that, due to their sessile lifestyle, cannot escape adverse environmental conditions. Plant hormones play a key role in the integration of signals triggered by endogenous and exogenous stimuli. To dissect the involvement of plant hormones in signal integration, the interaction between ethylene and auxin in the regulation of a highly plastic phenotype, root elongation, was chosen as a model. Our initial studies have uncovered an unexpected role of ethylene in the precise spatiotemporal regulation of auxin biosynthesis. Current work using genome-wide ribosome footprinting is uncovering the molecular mechanisms linking this hormone perception to the activation of a novel gene-specific translational control mechanism. Characterization of one of the targets of this translational regulation indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. Our findings represent a new mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator in plants.