The aim in my research project is to understand the mechanisms of metabolic control of shoot elongation and wood formation in the model plant Populus.
We want to understand how plant hormones and other metabolites are involved in the control of plant development, and how different environmental cues, such as photoperiod, affect the metabolic control of growth and development. The metabolic control of growth and developement are studied by using both targeted and untargeted metabolomics approaches.

Thomas Moriz 1150Gibberellins (GAs) are a group of tetracyclic diterpenes,some of which are essential endogenous regulators that influence growth and development events throughout the life cycle of a plant, e.g. shoot elongation, expansion and shape of leaves, flowering and seed germination. Our project is concerned with the role of GAs in plant development, and daylength responses, focusing on the tree hybrid aspen (Populus tremula x P. tremuloides) as a model system. Our approach for studying the role of GAs in trees is to study endogenous expression of GA biosynthetic and signalling genes and to transform Populus
with genes encoding those genes.

moritz_1moritz_2
Populus transformed with the AtGA20ox1 under the control of the 35S promoter shows elongated internodes, longer petioles and larger leaves, reduced root formation and increased shoot biomass.We have also char- acterized the GA receptor, GID1 in Populus. Four orthologs of GID1 have been identified in Populus tremula x P. tremuloides (PttGID1.1 to 1.4). When PttGID1.1 and PttGID1.3 were overexpressed in Populus with a 35S promoter, overexpressors shared several similar phenotypic traits with previously described 35S:AtGA20ox1 overexpressors, including rapid growth and increased elongation.
We are also studying the role of GAs and other signaling compounds in wood formation.The role of GAs is done by both using transgenic Populus with increased levels of GAs and sig- nalling,and by predicting where GAs are formed and perceived during wood formation. For example, we have quantified GAs and analyzed the expression of GA biosynthesis genes and genes with predicted roles in GA signalling in tangential sections across the cambial region of aspen trees (Populus tremula).The results
show, for example inter alia, that the bioactive GA and GA 14 predominantly occur in the zone of expansion of xylem cells.
Studies with transgenic Populus overexpressing AtGA20ox1 or PttGID1 with 35S or a xylem-specific promoter, suggest that GAs are required for two distinct processes in wood formation with tissue-specific signalling pathways: xylogenesis, mediated by GA signalling in the cambium, and fibre elongation in developing xylem.
.
moritz_3By using a metabolomics approach we are also studying how specific patterns of metabolites, including signalling compounds, are vary in different regions of the wood-forming zone in Populus. From the data we can conclude that cambial activity, cell expansion and secondary cell wall thickening are tightly coupled processes, Many of these patterns can be explained on the basis of the developmental processes taking place within these regions, e.g. in the cambium.
Many woody species with indeterminate growth show com- plete cessation of elongation growth after only a few weeks in short photoperiods. In hybrid aspen transformed with the oat PHYA gene, the dwarf phenotype is correlated with a reduc- tion in GA levels, but in short photoperiods there is no further reduction in GA contents, in marked contrast to the pattern in wild-type plants.These observations imply that GAs have an important role as signals in the photoperiodic regulation of shoot elongation.We have also been studying transgenic GA plants to elucidate how changes in GA levels and signalling affect photoperiodic growth. Studies in PHYA and GA biosynthesis/ signalling overexpressors are used with transcriptomic and me- tabolomic approaches to elucidate the early signalling pathways in short-day induced growth cessation, including identification of new putative signalling compounds.
sweden_greySvensk samanfattning

Key Publications

  • Mauriat M, Sandberg L, Moritz T (2011). Proper gibberellin localization in vascular tissue is required to control auxin dependent leaf development and bud outgrowth in hybrid aspen. Plant J. 67: 805-816.
  • Mauriat M, Moritz T (2009). Analyses of GA20ox- and GID1-overexpressing Populus suggest gibberellins play two distinct roles in wood formation. Plant J. 58: 989-1003.
  • Israelsson M, Sundberg B, Moritz T (2005). Tissue-specific localisation of gibberellins in wood-forming tissues in aspen. Plant J. 44: 494-504.
  • Jonsson P, Johansson A, Gullberg J, Trygg J, A J, Grung B, Marklund S, Sjöström M, Antti H, Moritz T (2005). High through-put data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses Anal. Chem. 77: 5635-5642.
  • Eriksson M, Israelsson M, Olsson O, Moritz T (2000). Increased gibberellin biosynthesis in transgenic trees promotes growth, biomass production and xylem fibre length. Nature Biotech. 784-788.

CV Dr. Thomas Moritz

  • 1985: BSc, Umeå University
  • 1990: PhD, Swedish University of Agricultural Sciences 1991: Post doc, Long Ashton Research Station, Bristol, UK
  • 1992: Assistant Professor, Swedish University of Agricultural Sciences
  • 1997: Docent, Swedish University of Agricultural Sciences
  • 2002: Professor, Swedish University of Agricultural Sciences
  • 2007: Head of Department (Dept. Forest Genetics and Plant Physiology)
  • 2013: Director Swedish Metabolomics Centre

Publications list

  1. Metabolome and transcriptome profiling reveal new insights into somatic embryo germination in Norway spruce (Picea abies)
    Tree Physiol. 2017 Jun 28:1-15 [Epub ahead of print]
  2. Enhanced Secondary- and Hormone Metabolism in Leaves of Arbuscular Mycorrhizal Medicago truncatula
    Plant Physiol. 2017, 175(1):392-411
  3. Nitrogen uptake and assimilation in proliferating embryogenic cultures of Norway spruce-Investigating the specific role of glutamine
    PLoS One. 2017, 12(8):e0181785 eCollection 2017
  4. Functional metabolomics as a tool to analyze Mediator function and structure in plants
    PLoS One. 2017 Jun 22;12(6):e0179640
  5. AtbHLH68 transcription factor contributes to the regulation of ABA homeostasis and drought stress tolerance in Arabidopsis thaliana
    Physiol Plant. 2017, 160(3):312-327
  6. Defense responses in aspen with altered pectin methylesterase activity reveal the hormonal inducers of tyloses
    Plant Physiol. 2017, 173(2):1409-1419
  7. Dissecting the metabolic role of mitochondria during developmental leaf senescence
    Plant Physiol. 2016, 172 (4):2132-2153
  8. Central Metabolic Changes in O3 and Herbivory Affect Photosynthesis and Stomatal Closure
    Plant Physiol 2016, 172 (3):2057-2078
  9. Seasonal Variation of Carbon Metabolism in the Cambial Zone of Eucalyptus grandis
    Front Plant Sci. 2016 Jun 28;7:932 eCollection 2016
  10. Integrated analysis of gene expression from carbon metabolism, proteome and metabolome, reveals altered primary metabolism in Eucalyptus grandis bark, in response to seasonal variation
    BMC Plant Biol. 2016;16(1):149
  11. Metabolomic Quality Assessment of EDTA Plasma and Serum Samples
    Biopreserv Biobank. 2016,14(5):416-423
  12. Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by 13C labelling
    J Exp Bot. 2016, 67(10):3123-3135
  13. Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects
    Mol Biosyst. 2016, 12 (4):1287-1298
  14. Quantitative proteomics reveals protein profiles underlying major transitions in aspen wood development
    BMC Genomics 2016, 17(1):119
  15. Cell-type specific metabolic profiling of Arabidopsis thaliana protoplasts as a tool for plant systems biology
    Metabolomics. 2015;11(6):1679-1689
  16. Silencing C19-GA 2-oxidases induces parthenocarpic development and inhibits lateral branching in tomato plants
    J Exp Bot. 2015, 66(19):5897-5910
  17. Carbon-13 tracking after 13CO2 supply revealed diurnal patterns of wood formation in aspen
    Plant Physiol. 2015; 168(2):478-489
  18. Transgenic hybrid aspen trees with increased gibberellin (GA) concentrations suggest that GA acts in parallel with FLOWERING LOCUS T2 to control shoot elongation
    New Phytologist 2015, 205(3):1288-95
  19. No Evidence of Geographical Structure of Salicinoid Chemotypes within Populus Tremula
    PLoS ONE 2014; 9(10):e107189
  20. High Lipid Order of Arabidopsis Cell Plate Membranes Mediated by Sterol and DYNAMIN-RELATED PROTEIN1A Function
    Plant J. 2014, 80(5):745-757
  21. CHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication
    Nat Commun. 2014; 5:4276

  22. Maladjusted host immune responses induce experimental cerebral malaria-like pathology in a murine borrelia and Plasmodium co-infection model
    PLoS One. 2014; 9(7):e103295

  23. Serum metabolomic biomarkers of dementia
    Dement Geriatr Cogn Dis Extra. 2014, 4(2):252-62
  24. Metabolite and Peptide Levels in Plasma and CSF Differentiating Healthy Controls from Patients with Newly Diagnosed Parkinson's Disease
    J Parkinsons Dis. 2014; 4(3):549-560
  25. Aspen pectate lyase PtxtPL1-27 mobilizes matrix polysaccharides from woody tissues and improves saccharification yield
    Biotechnol Biofuels. 2014; 7(1):11
  26. A quantitative LC/MS method targeting urinary 1-methyl-4-imidazoleacetic acid for safety monitoring of the global histamine turnover in clinical studies
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY 2014; 406(6):1751-1762
  27. Gibberellins inhibit adventitious rooting in hybrid aspen and Arabidopsis by affecting auxin transport
    Plant J. 2014, 78(3):372-384
  28. OnPLS integration of transcriptomic, proteomic and metabolomic data shows multi-level oxidative stress responses in the cambium of transgenic hipI-superoxide dismutase Populus plants
    BMC Genomics. 2013; 14:893
  29. ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis
    The Plant Journal, 2013; 76(5):811-824
  30. Businge E, Bygdell J, Wingsle G, Moritz T, Egertsdotter U
    The effect of carbohydrates and osmoticum on storage reserve accumulation and germination of Norway spruce somatic embryos
    Physiol Plant. 2013; 149(2):273-285
  31. Miranda H, Cheregi O, Netotea S, Hvidsten TR, Moritz T, Funk C
    Co-expression analysis, proteomic and metabolomic study on the impact of a Deg/HtrA protease triple mutant in Synechocystis sp. PCC 6803 exposed to temperature and high light stress
    J. of Proteomics 2013, 78:94-311
  32. Zang H, Moritz T, Norstedt G, Hirschberg AL, Tollet-Egnell P
    Effects of oestrogen and testosterone therapy on serum metabolites in postmenopausal women
    Clin Endocrinol (Oxf). 2012 77(2):288-95
  33. Surowiec I, Nowik W, Moritz T
    Mass spectrometric identification of new minor indigoids in shellfish purple dye from Hexaplex trunculus
    DYES AND PIGMENTS 2012 94(2):363-369
  34. Madsen R, Rantapää-Dahlqvist S, Lundstedt T, Moritz T, Trygg J
    Metabolic responses to change in disease activity during tumor necrosis factor inhibition in patients with rheumatoid arthritis
    J Proteome Res. 2012 11(7):3796-804
  35. Gerber L, Eliasson M, Trygg J, Moritz T, Sundberg B
    Multivariate curve resolution provides a high-throughput data processing pipeline for pyrolysis-gas chromatography/mass spectrometry
    JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS 2012 95:95-100
  36. Madsen R, Banday VS, Moritz T, Trygg J, Lejon K
    Altered metabolic signature in pre-diabetic NOD mice
    PLoS One. 20127(4):e35445. Epub 2012 Apr 13
  37. Chorell E, Svensson MB, Moritz T, Antti H
    Physical fitness level is reflected by alterations in the human plasma metabolome
    Mol Biosyst. 2012 Apr;8(4):1187-96. Epub 2012 Jan 27
  38. Wuolikainen A, Andersen PM, Moritz T, Marklund SL, Antti H
    ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations
    Mol Genet Metab. 2012 105(3):472-478
  39. Danielsson APH, Moritz T, Mulder H, Spegel, P
    Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design
    METABOLOMICS 2012 8(1):50-63
  40. Businge E, Brackmann K, Moritz T, Egertsdotter U
    Metabolite profiling reveals clear metabolic changes during somatic embryo development of Norway spruce (Picea abies)
    Tree Physiol. 2012 , 32(2):232-244
  41. Mauriat M, Sandberg LG, Moritz T
    Proper gibberellin localization in vascular tissue is required to control auxin-dependent leaf development and bud outgrowth in hybrid aspen
    The Plant Journal: 2011, 67(5), 805-816
  42. Abreu IN, Ahnlund M, Moritz T, Albrectsen BR
    UHPLC-ESI/TOFMS determination of salicylate-like phenolic gycosides in Populus tremula leaves
    Journal of Chemical Ecology: 2011 37:857-870
  43. Ma J, Hanssen M, Lundgren K, Hernández L, Delatte T, Ehlert A, Liu C-M, Schluepmann H, Dröge-Laser W, Moritz T, Smeekens S, Hanson J
    The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism
    New Phytologist: 2011, 191:733–745
  44. Madsen RK, Lundstedt T, Gabrielsson J, Sennbro CJ, Alenius GM, Moritz T, Rantapaa-Dahlqvist S, Trygg J
    Diagnostic properties of metabolic perturbations in rheumatoid arthritis
    Arthritis Research: 2011 13:R19
  45. Wuolikainen A, Moritz T, Marklund SL, Antti H, Andersen PM
    Disease-related changes in the cerebrospinal fluid metabolome inamytrophic lateral sclerosis detected by GC/TOFMS
    PLoS one: 2011 6:e17947
  46. Dubois V, Moritz T, Garcia-Martinez JL
    Comparison of the role of gibberellins and ethylene in response to submergence of two lowland rice cultivars, Senia and Bomba
    Journal of Plant Physiology: 2011 168:233-241
  47. Danielsson APH, Moritz T, Mulder H, Spégel P
    Development and optimization of a metabolomic method for analysis of adherent cell cultures
    Analytical Biochemistry: 2010 404:30-39
  48. Renberg L, Johansson AI, Shutova T, Stenlund H, Aksmann A, Raven JA, Gardeström P, Moritz T, Samuelsson G
    A metabolomic approach to study major metabolite changes during acclimation to limiting CO2 in Chlamydomonas reinhardtii
    Plant Physiology: 2010 154:187-196
  49. Krus U, Kotova O, Spegel P, Hallgard E, Sharoyko VV, Vedin A, Moritz T,  Sugden MC, Koeck T, Mulder H
    Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells
    Biochemical Journal: 2010 429:205-213
  50. Waldenström A, Haney M, Biber B, Kavianipour M, Moritz T, Strandén P, Wikström G, Ronquist G
    Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: an experimental study in the pig
    Acta Physiologica: 2010 199:1-9
  51. Spégel P, Danielsson APH, Bacos K, Nagorny CLF, Moritz T, Mulder H, Filipsson K
    Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism
    Metabolomics: 2010 6:56-66
  52. Kozarewa I, Ibáñez C, Johansson M, Ögren E, Mozley D, Nylander E, Chono M, Moritz T, Eriksson ME
    Alteration of PHYA expression change circadian rhythms and timing of bud set in Populus
    Plant Molecular Biology: 2010 73:143-156
  53. Hoffman DE, Jonsson P, Bylesjö M, Trygg J, Antti H, Eriksson ME, Moritz T
    Changes in diurnal patterns within the Populus transcriptome and metabolome in response to photoperiod variation
    Plant, Cell & Environment: 2010 33:1298-1313
  54. Van der Merwe MJ, Osorio S, Moritz T, Nunes-Nesi A, Fernie AR
    The role and regulation of the tricarboxylic acid cycle in Solanum lycopersicum roots
    South African Journal of Botany: 2009 75:424
  55. van der Merwe MJ, Osorio S, Moritz T, Nunes-Nesi A, Fernie AR
    Decreased mitochondrial activities of malate dehydrogenase and fumarase in tomato lead to altered root growth and architecture via diverse mechanisms
    Plant Physiology: 2009 149:653-669
  56. Wuolikainen A, Hedenstrom M, Moritz T, Marklund SL, Antti H, Andersen PM
    Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALS
    Amyotrophic Lateral Sclerosis: 2009 10:229-236
  57. Redestig H, Fukushima A, Stenlund H, Moritz T, Arita M, Saito K, Kusano M
    Compensation for systematic cross-contribution improves normalization of mass spectrometry based metabolomics data
    Analytical chemistry: 2009 81:7974-7980
  58. Galindo FG, Dejmek P, Lundgren K, Rasmusson AG, Vicente A, Moritz T
    Metabolomic evaluation of pulsed electric field-induced stress on potato tissue
    Planta: 2009 230:469-479
  59. Chorell E, Moritz T, Branth S, Antti H, Svensson MB
    Predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise
    Journal of Proteome Research: 2009 8:2966-2977
  60. Mauriat M, Moritz T
    Analyses of GA20ox- and GID1-over-expressing aspen suggest that gibberellins play two distinct roles in wood formation
    The Plant Journal: 2009 58:989-1003
  61. Petersson SV, Johansson AI, Kowalczyk M, Makoveychuk A, Wang JY, Moritz T, Grebe M, Benfey PN, Sandberg G, Ljung K
    An auxin gradient and maximum in the Arabidopsis root apex shown by high-resolution cell-specific analysis of IAA distribution and synthesis
    The Plant Cell: 2009 21:1659-1668
  62. Hytonen T, Elomaa P, Moritz T, Junttila O
    Gibberellin mediates daylength-controlled differentiation of vegetative meristems in strawberry (Fragaria x ananassa Duch)
    BMC Plant Biology: 2009 9:18, 12 pp
  63. Frenkel M, Külheim C, Johansson Jänkänpää H, Skogström O, Dall'Osto L, Ågren J, Bassi R, Moritz T, Moen J, Jansson S
    Improper excess light energy dissipation in Arabidopsis results in a metabolic reprogramming
    BMC Plant Biology: 2009 9:12
  64. Zheng BS, Rönnberg E, Virtanen L, Salminen TA, Lundgren K, Moritz T, Edqvist J
    Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings
    Journal of Expreimental Botany: 2008 59(12):3485-3499
  65. Van Der Merwe MJ, Osorio S, Moritz T, Nunes-Nesi A, Fernie AR
    Decreased mitochondrial activities of malate dehydrogenase and fumarase in Solanum lycopersicum lead to altered root growth and architecture via diverse mechanisms

    Plant Physiology: 2008 149:653-669
  66. Bylesjö M, Nilsson R, Srivastava V, Grönlund A, Johansson AI, Jansson S, Karlsson J, Moritz T, Wingsle G, Trygg J
    Integrated Analysis of Transcript, Protein and Metabolite Data To Study Lignin Biosynthesis in Hybrid Aspen
    Journal of Proteome Research: 2009 8:199-210
  67. Depuydt S, Dolezal K, Van Lijsebettens M, Moritz T, Holsters M, Vereecke D
    Modulation of the hormone setting by Rhodococcus fascians results in ectopic KNOX activation in Arabidopsis
    Plant Physiology: 2008 146:1267-1281
  68. Andersen G, Björnberg O, Polakova S, Pynyaha Y, Rasmussen A, Moller K, Hofer A, Moritz T, Sandrini MPB, Merico A-M, Compagno C, Åkerlund H-E, Gojkovic Z, Piskur J
    A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes
    Journal of Molecular Biology: 2008 380:656-666
  69. Gallego-Giraldo L, Gisbert C, Garcia-Martinez JL, Moritz T, Lopez-Diaz I
    Gibberellin homeostasis in tobacco is regulated by gibberelllin metabolism genes with different gibberellin sensitivity
    Plant and Cell Physiology: 2008 49:679-690
  70. Guy C, Kopka J, Moritz T
    Plant metabolomics coming of age
    Physiologia Plantarum: 2008 132:113-116
  71. Gutierrez L, Mauriat M, Guénin S, Pelloux J, Lefebvre JF, Louvet R, Rusterucci C, Moritz T, Guerineau F, Bellini C, Van Wuytswinkel O
    The lack of a systematic validation of reference genes: a serious pitfall undervalued in reverse transcription-polymerase chain reaction (RT-PCR) analysis in plants.
    Plant Biotechnology Journal: 2008 6:609-618
  72. Men S, BouttéY, Ikeda Y, Li X, Palme K, Stierhof YD, Hartmann MA, Moritz T, Grebe M
    Sterol-dependent endocytosis mediates post-cytokinetic acquisition of PIN2 auxin efflux carrier polarity
    Nature Cell Biology: 2008 10:237-244
  73. De Grauwe L, Chaerle L, Dugardeyn J, Decat J, Rieu I, Vriezen WH, Moritz T, Beemster GTS, Phillips AL, Harberd NP, Hedden P, Van Der Straeten D
    Reduced gibberellin response effects ethylene biosynthesis and responsiveness in the Arabidopsis gai eto2-1 double mutant
    New Phytologist: 2008 177:128-141
  74. Bruce SJ, Jonsson P, Antti H., Cioarec O, Trygg J, Marklund SL, Moritz T
    Evaluation of a protocol for metabolic prifiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis
    Analytical Biochemistry: 2008 372: 237-249
  75. Wiklund S, Johansson E, Sjöström L, Mellerowicz EJ, Edlund U, Shockcor JP, Gottfries J, Moritz T, Trygg J
    Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
    Analytical Chemistry: 2008 80: 115-122
  76. Bylesjö M, Eriksson D, Kusano M, Moritz T, Trygg J
    Data integration in plant biology: the O2PLS method for combined modeling of transcript and metabolite data
    Plant Journal: 2008 52:1181-1191
  77. Vandenbussche F, Vancompernolle B, Rieu I, Ahmad M, Phillips A, Moritz T, Hedden P, Van der Straeten D
    Ethylene-induced Arabidopsis hypocotyl elongation is dependent on but not mediated by gibberellins

    Journal of Experimental Botany: 2007 58:4269-4281
  78. Kusano M, Fukushima A, Arita M, Jonsson P, Moritz T, Kobayashi M, Hayashi N, Tohge T, Saito K
    Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana
    BMC Systems Biology: 2007 1:53
  79. Thysell E, Pohjanen E, Lindberg J, Schuppe-Koistinen I, Moritz T, Jonsson P, Antti H
    Reliable profile detection in comparative metabolomics
    OMICS: 2007 11:209-224
  80. Kusano M, Fukushima A, Kobayashi M, Hayashi N, Jonsson P, Moritz T, Ebana K, Saito K
    Application of a metabolomic method combining one- dimensional and two- dimensional gas chromatography- time- of- flight/mass spectrometry to metabolic phenotyping of natural variants in rice
    Journal of Chromatography B: 2007 855:71-79
  81. Björklund S, Antti H, Uddestrand I, Moritz T, Sundberg B
    Cross-talk between gibberellin and auxin in development of Populus wood: gibberellin stimulates polar auxin transport and has a common transcriptome with auxin
    The Plant Journal: 2007 52:499-511
  82. Bylesjo M, Eriksson D, Sjodin A, Jansson S, Moritz T, Trygg J
    Orthogonal projections to latent structures as a strategy for microarray data normalization.
    BMC Bioinformatics 2007, 8:207.
  83. Achard P, Baghour M, Chapple A, Hedden P, Van Der Straeten D, Genschik P, Moritz T, Harberd NP
    The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes.
    Proceedings of the National Academy of Sciences of the United States of America: 2007 104:6484-6489
  84. Druart N, Johansson A, Baba K, Schrader J, Sjödin A, Bhalerao RR, Resman L, Trygg J, Moritz T, Bhallerao RP
    Environmental and hormonal regulation of the activity-dormancy cycle in the cambial meristem involves stage-specific modulation of transcriptional and metabolic networks
    The Plant Journal: 2007 50:557-573
  85. Pohjanen E, Thysell E, Lindberg J, Schuppe-Koistinen I, Moritz T, Jonsson P, Antti H
    Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics
    Metabolomics: 2007 2:257-268
  86. Bylesjo M, Sjodin A, Eriksson D, Antti H, Moritz T, Jansson S, Trygg J
    MASQOT-GUI: spot quality assessment for the two-channel microarray platform
    Bioinformatics: 2006 22:2554-2555
  87. Keller T, Abbott J, Moritz T, Doerner P
    Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development
    Plant Cell: 2006 18:598-611
  88. Andersson-Gunneras S, Mellerowicz EJ, Love J, Segerman B, Ohmiya Y, Coutinho PM, Nilsson P, Henrissat B, Moritz T, Sundberg B
    Biosynthesis of cellulose-enriched tension wood in Populus: global analysis of transcripts and metabolites identifies biochemical and developmental regulators in secondary wall biosynthesis
    The Plant Journal: 2006 45:144-165
  89. Achard P, Cheng H, De Grauwe L, Decat J, Schoutteten H, Moritz T, Van der Straeten D, Peng JR, Harberd NP
    Integration of plant responses to environmentally activated phytohormonal signals
    Science: 2006 311:91-94
  90. Benschop JJ, Bou J, Peeters AJM, Wagemaker N, Guhl K, Ward D, Hedden P, Moritz T, Voesenek L
    Long-term submergence-induced elongation in Rumex palustris requires abscisic acid-dependent biosynthesis of gibberellin
    Plant Physiology: 2006 141:1644-1652
  91. Jonsson P, Johansson ES, Wuolikainen A, Lindberg J, Schuppe-Koistinen I, Kusano M, Sjostrom M, Trygg J, Moritz T, Antti H
    Predictive metabolite profiling applying hierarchical multivariate curve resolution to GC-MS datas - A potential tool for multi-parametric diagnosis
    Journal of Proteome Research: 2006 5:1407-1414
  92. King RW, Moritz T, Evans LT, Martin J, Andersen CH, Blundell C, Kardailsky I, Chandler PM
    Regulation of flowering in the long-day grass Lolium temulentum by Gibberellins and the FLOWERING LOCUS T gene
    Plant Physiology: 2006 141:498-507
  93. Ruonala R, Rinne PLH, Baghour M, Moritz T, Tuominen H, Kangasjarvi J
    Transitions in the functioning of the shoot apical meristem in birch (Betula pendula) involve ethylene
    Plant Journal: 2006 46:628-640
  94. Jiye A, Trygg J, Gullberg J, Johansson AI, Jonsson P, Antti H, Marklund SL, Moritz T
    Extraction and GC/MS analysis of the human blood plasma metabolome
    Anal Chem: 2005 77:8086-8094
  95. Jonsson P, Bruce SJ, Moritz T, Trygg J, Sjostrom M, Plumb R, Granger J, Maibaum E, Nicholson JK, Holmes E, Antti H
    Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets
    Analyst: 2005 130:701-707
  96. Schauer N, Steinhauser D, Strelkov S, Schomburg D, Allison G, Moritz T, Lundgren K, Tunali UR, Forbes MG, Willmitzer L, Fernie AR, Kopka J
    GC-MS libraries for the rapid identification of metabolites in complex biological samples
    FEBS Lett: 2005 579:1332-1337
  97. Jonsson P, Johansson AI, Gullberg J, Trygg J, A J, Grung B, Marklund S, Sjostrom M, Antti H, Moritz T
    High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses
    Anal Chem: 2005 77:5635-5642
  98. Israelsson M, Sundberg B, Moritz T
    Tissue-specific localization of gibberellins and expression of gibberellin-biosynthetic and signaling genes in wood-forming tissues in aspen
    Plant J: 2005 44:494-504
  99. Jonsson P, Gullberg J, Nordstrom A, Kusano M, Kowalczyk M, Sjostrom M, Moritz T
    A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS
    Anal Chem: 2004 76:1738-1745
  100. Curaba J, Moritz T, Blervaque R, Parcy Fo, Raz V, Herzog M, Vachon G
    AtGA3ox2, a key gene responsible for bioactive gibberellin biosynthesis, is regulated during embryogenesis by LEAFY COTYLEDON2 and FUSCA3 in Arabidopsis
    Plant Physiol: 2004 136:3660-3669
  101. Israelsson M, Mellerowicz E, Chono M, Gullberg J, Moritz T
    Cloning and overproduction of gibberellin 3-oxidase in hybrid aspen trees. Effects on gibberellin homeostasis and development
    Plant Physiol: 2004 135:221-230
  102. Nordstrom A, Tarkowski P, Tarkowska D, Dolezal K, Astot C, Sandberg G, Moritz T
    Derivatization for LC electrospray ionization-MS: A tool for improving reversed-phase separation and ESI responses of bases, ribosides, and intact nucleotides
    Analytical Chemistry: 2004 76:2869-2877
  103. Nordstrom A, Tarkowski P, Tarkowska D, Dolezal K, Astot C, Sandberg G, Moritz T
    Derivatization for LC-electrospray ionization-MS: a tool for improving reversed-phase separation and ESI responses of bases, ribosides, and intact nucleotides
    Anal Chem: 2004 76:2869-2877
  104. Gullberg J, Jonsson P, Nordstrom A, Sjostrom M, Moritz T
    Design of experiments: an efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry
    Anal Biochem: 2004 331:283-295
  105. Corbesier L, Kustermans G, Perilleux C, Melzer S, Moritz T, Havelange A, Bernier G
    Gibberellins and the floral transition in Sinapis alba
    Physiologia Plantarum: 2004 122:152-158
  106. Jiye A, Trygg J, Gullberg J, Moritz T, Marklund S
    Global analysis of low-molecular-weight compounds in human plasma using GC/TOF-MS
    Drug Metabolism Reviews: 2004 36:246-246
  107. Cox MCH, Benschop JJ, Vreeburg RAM, Wagemaker CAM, Moritz T, Peeters AJM, Voesenek LACJ
    The roles of ethylene, auxin, abscisic acid, and gibberellin in the hyponastic growth of submerged Rumex palustris petioles
    Plant Physiol: 2004 136:2948-2960
  108. Andersson-Gunneras S, Hellgren JM, Bjorklund S, Regan S, Moritz T, Sundberg B
    Asymmetric expression of a poplar ACC oxidase controls ethylene production during gravitational induction of tension wood
    Plant Journal: 2003 34:339-349
  109. Israelsson M, Eriksson ME, Hertzberg M, Aspeborg H, Nilsson P, Moritz T
    Changes in gene expression in the wood-forming tissue of transgenic hybrid aspen with increased secondary growth
    Plant Mol Biol: 2003 52:893-903
  110. King RW, Evans LT, Mander LN, Moritz T, Pharis RP, Twitchin B
    Synthesis of gibberellin GA(6) and its role in flowering of Lolium temulentum
    Phytochemistry: 2003 62:77-82
  111. Eriksson ME, Moritz T
    Daylength and spatial expression of a gibberellin 20-oxidase isolated from hybrid aspen (Populus tremula L. x P. tremuloides Michx.)
    Planta: 2002 214:920-930
  112. Welling A, Moritz T, Palva ET, Junttila O
    Independent activation of cold acclimation by low temperature and short photoperiod in hybrid aspen
    Plant Physiol: 2002 129:1633-1641
  113. Peng JR, Richards DE, Moritz T, Ezura H, Carol P, Harberd NP
    Molecular and physiological characterization of Arabidopsis GAI alleles obtained in targeted Ds-tagging experiments
    Planta: 2002 214:591-596
  114. Uggla C, Magel E, Moritz T, Sundberg B
    Function and dynamics of auxin and carbohydrates during earlywood/latewood transition in scots pine
    Plant Physiol: 2001 125:2029-2039
  115. Gocal GFW, Sheldon CC, Gubler F, Moritz T, Bagnall DJ, MacMillan CP, Li SF, Parish RW, Dennis ES, Weigel D, King RW
    GAMYB-like genes, flowering, and gibberellin signaling in Arabidopsis
    Plant Physiology: 2001 127:1682-1693
  116. King KE, Moritz T, Harberd NP
    Gibberellins are not required for normal stem growth in Arabidopsis thaliana in the absence of GAI and RGA
    Genetics: 2001 159:767-776
  117. King RW, Moritz T, Evans LT, Junttila O, Herlt AJ
    Long-day induction of flowering in Lolium temulentum involves sequential increases in specific gibberellins at the shoot apex
    Plant Physiol: 2001 127:624-632
  118. Astot C, Dolezal K, Nordstrom A, Wang Q, Kunkel T, Moritz T, Chua NH, Sandberg G
    An alternative cytokinin biosynthesis pathway
    Proc Natl Acad Sci U S A: 2000 97:14778-14783
  119. Astot C, Dolezal K, Moritz T, Sandberg G
    Deuterium in vivo labelling of cytokinins in Arabidopsis thaliana analysed by capillary liquid chromatography/frit-fast atom bombardment mass spectrometry
    J Mass Spectrom: 2000 35:13-22
  120. Eriksson ME, Israelsson M, Olsson O, Moritz T
    Increased gibberellin biosynthesis in transgenic trees promotes growth, biomass production and xylem fiber length
    Nature Biotechnology 2000 18:784-788
  121. Eklof S, Astot C, Sitbon F, Moritz T, Olsson O, Sandberg G
    Transgenic tobacco plants co-expressing Agrobacterium iaa and ipt genes have wild-type hormone levels but display both auxin- and cytokinin-overproducing phenotypes
    Plant Journal: 2000 23:279-284
  122. Valkonen JPT, Moritz T, Watanabe KN, Rokka VM
    Dwarf (di)haploid pito mutants obtained from a tetraploid potato cultivar (Solanum tuberosum subsp tuberosum) via anther culture are defective in gibberellin biosynthesis
    Plant Science: 1999 149:51-57
  123. Peng JR, Richards DE, Moritz T, Cano-Delgado A, Harberd NP
    Extragenic suppressors of the Arabidopsis gai mutation alter the dose-response relationship of diverse gibberellin responses
    Plant Physiology: 1999 119:1199-1207
  124. Fridborg I, Kuusk S, Moritz T, Sundberg E
    The Arabidopsis dwarf mutant shi exhibits reduced gibberellin responses conferred by overexpression of a new putative zinc finger protein
    Plant Cell: 1999 11:1019-1031
  125. Backlund A, Moritz T
    Phylogenetic implications of an expanded valepotriate distribution in the Valerianaceae
    Biochemical Systematics and Ecology: 1998 26:309-335
  126. Astot C, Dolezal K, Moritz T, Sandberg G
    Precolumn derivatization and capillary liquid chromatographic/ frit -fast atom bombardment mass spectrometric analysis of cytokinins in Arabidopsis thaliana
    J Mass Spectrom: 1998 33:892-902
  127. Moritz T, Schmulling T
    The gibberellin content of rolA transgenic tobacco plants is specifically altered
    Journal of Plant Physiology: 1998 153:774-776
  128. Wingsle G, Moritz T
    Analysis of ascorbate and dehydroascorbate in plant extracts by high-resolution selected ion monitoring gas chromatography mass spectrometry
    Journal of Chromatography A: 1997 782:95-103
  129. Eklof S, Astot C, Blackwell J, Moritz T, Olsson O, Sandberg G
    Auxin-cytokinin interactions in wild-type and transgenic tobacco
    Plant and Cell Physiology: 1997 38:225-235
  130. Olsen JE, Junttila O, Nilsen J, Eriksson ME, Martinussen I, Olsson O, Sandberg G, Moritz T
    Ectopic expression of oat phytochrome A in hybrid aspen changes critical daylength for growth and prevents cold acclimatization
    Plant Journal: 1997 12:1339-1350
  131. Eriksson ME, Moritz T
    Isolation of a cDNA Encoding a Phytochrome A (Accession No.AJ001318) from Populus tremula x tremuloides. (PGR97-186)
    Plant Physiology: 1997 115:1731-1731
  132. Olsen JE, Junttila O, Moritz T
    Long- day induced bud break in Salix pentandra is associated with transiently elevated levels of GA(1) and gradual increase in indole- 3- acetic acid
    Plant and Cell Physiology: 1997 38:536-540
  133. Uggla C, Moritz T, Sandberg G, Sundberg B
    Auxin as a positional signal in pattern formation in plants
    Proc Natl Acad Sci U S A: 1996 93:9282-9286
  134. Ashihara H, Monteiro AM, Moritz T, Gillies FM, Crozier A
    Catabolism of caffeine and related purine alkaloids in leaves of Coffea arabica L
    Planta: 1996 198:334-339
  135. Eklof S, Astot C, Moritz T, Blackwell J, Olsson O, Sandberg G
    Cytokinin metabolites and gradients in wild type and transgenic tobacco with moderate cytokinin over-production
    Physiologia Plantarum: 1996 98:333-344
  136. Moritz T, Sundberg B
    Endogenous cytokinins in the vascular cambial region of Pinus sylvestris during activity and dormancy
    Physiologia Plantarum: 1996 98:693-698
  137. Nilsson O, Moritz T, Sundberg B, Sandberg G, Olsson O
    Expression of the Agrobacterium rhizogenes rolC Gene in a Deciduous Forest Tree Alters Growth and Development and Leads to Stem Fasciation
    Plant Physiol: 1996 112:493-502
  138. Wang Q, Little CHA, Moritz T, Oden PC
    Identification of endogenous gibberellins, and metabolism of tritiated and deuterated GA(4), GA(9) and GA(20), in Scots pine (Pinus sylvestris) shoots
    Physiologia Plantarum: 1996 97:764-771
  139. PerezAmador MA, Carbonell J, Navarro JL, Moritz T, Beale MH, Lewis MJ, Hedden P
    N-4-hexanoylspermidine, a new polyamine-related compound that accumulates during ovary and petal senescence in pea
    Plant Physiology: 1996 110:1177-1186
  140. Amador MAP, Carbonell J, Navarro JL, Moritz T, Beale MH, Lewis MJ, Hedden P
    N4-Hexanoylspermidine, a New Polyamine-Related Compound That Accumulates during Ovary and Petal Senescence in Pea
    Plant Physiol: 1996 110:1177-1186
  141. Olsen JE, Junttila O, Moritz T
    A localised decrease of GA(1) in shoot tips of Salix pentandra seedlings precedes cessation of shoot elongation under short photoperiod
    Physiologia Plantarum: 1995 95:627-632
  142. Edlund A, Eklof S, Sundberg B, Moritz T, Sandberg G
    A Microscale Technique for Gas- Chromatography Mass- Spectrometry Measurements of Picogram Amounts of Indole- 3- Acetic- Acid in Plant-Tissues
    Plant Physiology: 1995 108:1043-1047
  143. Moritz T
    Biological-Activity, Identification and Quantification of Gibberellins in Seedlings of Norway Spruce (Picea-Abies) Grown under Different Photoperiods
    Physiologia Plantarum: 1995 95:67-72
  144. Moritz T, Olsen JE
    Comparison between High-Resolution Selected-Ion Monitoring, Selected Reaction Monitoring, and 4-Sector Tandem Mass-Spectrometry in Quantitative-Analysis of Gibberellins in Milligram Amounts of Plant-Tissue
    Analytical Chemistry: 1995 67:1711-1716
  145. Wang Q, Little CHA, Moritz T, Oden PC
    Effects of prohexadione on cambial and longitudinal growth and the levels of endogenous gibberellins A(1),  A(3),  A(4), and A(9) and indole- 3- acetic acid in Pinus sylvestris shoots
    Journal of Plant Growth Regulation: 1995 14:175-181
  146. Olsen JE, Moritz T, Jensen E, Junttila O
    Lack of Effect of Photoperiod on Metabolism of Exogenous Ga(19) and Ga(1) in Salix Pentandra Seedlings
    Physiologia Plantarum: 1995 94:522-528
  147. Schneider G, Schmidt J, Moritz T
    Liquid-Chromatography Fast-Atom-Bombardment and Electrospray-Ionization Mass-Spectrometry of Gibberellin a(3) 1,2-Trans-Glycosyl Esters
    Journal of Mass Spectrometry: 1995 30:1489-1494
  148. Olsen JE, Jensen E, Junttila O, Moritz T
    Photoperiodic Control of Endogenous Gibberellins in Seedlings of Salix Pentandra
    Physiologia Plantarum: 1995 93:639-644
  149. Bollmark M, Chen HJ, Moritz T, Eliasson L
    Relations between cytokinin level, bud development and apical control in Norway spruce, Picea abies
    Physiologia Plantarum: 1995 95:563-568
  150. Moritz T, Monteiro AM
    Analysis of Endogenous Gibberellins and Gibberellin Metabolites from Dalbergia-Dolichopetala by Gas-Chromatography Mass-Spectrometry and High-Performance Liquid-Chromatography Mass-Spectrometry
    Planta: 1994 193:1-8
  151. Olsen JE, Moritz T, Jensen E, Junttila O
    Comparison of Endogenous Gibberellins in Roots and Shoots of Elongating Salix-Pentandra Seedlings
    Physiologia Plantarum: 1994 90:378-381
  152. Nilsson O, Moritz T, Imbault N, Sandberg G, Olsson O
    Hormonal Characterization of Transgenic Tobacco Plants Expressing the Rolc Gene of Agrobacterium-Rhizogenes Tl-DNA
    Plant Physiology: 1993 102:363-371
  153. Imbault N, Moritz T, Nilsson O, Chen HJ, Bollmark M, Sandberg G
    Separation and Identification of Cytokinins Using Combined Capillary Liquid-Chromatography Mass-Spectrometry
    Biological Mass Spectrometry: 1993 22:201-210
  154. Gref R, Moritz T, Lindgren D, Gohil S
    Variation and Inheritance of Manoyl Oxide Acid in Pinus-Sylvestris (L)
    Silvae Genetica: 1993 42:275-278
  155. Moritz T, Schneider G, Jensen E
    Capillary Liquid-Chromatography Fast-Atom-Bombardment Mass-Spectrometry of Gibberellin Glucosyl Conjugates
    Biological Mass Spectrometry: 1992 21:554-559
  156. Doumas P, Imbault N, Moritz T, Oden PC
    Detection and Identification of Gibberellins in Douglas-Fir (Pseudotsuga-Menziesii) Shoots
    Physiologia Plantarum: 1992 85:489-494
  157. Ostin A, Moritz T, Sandberg G
    Liquid- Chromatography Mass- Spectrometry of Conjugates and Oxidative Metabolites of Indole- 3- Acetic- Acid
    Biological Mass Spectrometry: 1992 21:292-298
  158. Moritz T
    The Use of Combined Capillary Liquid-Chromatography Mass-Spectrometry for the Identification of a Gibberellin Glucosylconjugate
    Phytochemical Analysis: 1992 3:32-37
  159. Moritz T, Oden PC
    Metabolism of Tritiated and Deuterated Gibberellin A9 in Norway Spruce (Picea-Abies) Shoots During the Period of Cone-Bud Differentiation
    Physiologia Plantarum: 1990 79:242-249
  160. Moritz T, Philipson JJ, Oden PC
    Quantitation of Gibberellin-A1, Gibberellin-A3, Gibberellin-A4, Gibberellin-A9 and an A9-Conjugate in Good-Flowering and Poor-Flowering Clones of Sitka Spruce (Picea-Sitchensis) During the Period of Flower-Bud Differentiation
    Planta: 1990 181:538-542
  161. Moritz T, Philipson JJ, Oden PC
    Quantitation of Gibberellin-A1, Gibberellin-A3, Gibberellin-A4, Gibberellin-A9, and a Putative Ag-Conjugate in Grafts of Sitka Spruce (Picea-Sitchensis) During the Period of Shoot Elongation
    Plant Physiology: 1990 93:1476-1481