The use of chemical biology to study plant cellular processes – subcellular trafficking
Plant Chemical Biology 22 NOV 2013
Haeger,A, Langowska M, Robert S

Abstract:
The endomembrane system is a complex network that plays an essential role in compensating for the sessile lifestyle of plants by mediating responses to environmental or developmental stimuli. This interconnected membrane and protein network has unique and vital functions; however, the mechanisms underlying regulation of the network remain largely elusive. The capacity of small molecules to act rapidly on dynamic systems makes them ideal tools to dissect vesicular trafficking in plants. Here we will illustrate several chemical genomics studies that have brought new insights into the plant endomembrane system. In addition, we will discuss natural toxins produced by nonplant organisms that target vesicular trafficking. Finally, we will highlight the advantages of using small molecules in comparison to genetic approaches to elucidate the trafficking network.
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